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Racial Disparities in Diabetes Care

2024 Healthcare Analytics View Research Paper

1. Overview

1-1. Background

Health disparities between people with disabilities and those without are poorly understood and under-researched. Factors that impact healthcare outcomes for disabled individuals include socioeconomic and environmental influences on healthcare system accessibility and quality of care.

Our study demonstrates disabilities like visual impairments intersect with race to influence the management of chronic conditions like diabetes. By examining disparities in the accessibility and quality of healthcare and subsequent health outcomes, this research illuminates the complex ways disability and race interact within healthcare systems.

The study leverages data from the TriNetX Research Network, encompassing electronic medical records from approximately 115 million patients across 83 de-identified healthcare organizations.

1-2. Research Questions

  1. Among patients with diabetes, are there significant differences in the prevalence of cardiopulmonary comorbidities between patients who are visually impaired versus those who are not?
  2. Are there racial disparities in the quality of diabetes-related care between those who are visually impaired not due to diabetes-related ophthalmic complications versus those who are not visually impaired?
  3. Are there racial disparities in health outcomes for persons with diabetes with a visual impairment diagnosis? How do these disparities compare to those with diabetes and no visual impairment diagnosis?

1-3. Hypotheses

1️⃣ Patients with visual impairment will have higher HbA1c and a higher rate of CKD(chronic kidney disease) regardless of race.

2️⃣ Patients with visual impairment will be less likely to have received the recommended standards of care for diabetes patients.

3️⃣ The disparities between those with visual impairment and those without these conditions, as identified in hypotheses 1 and 2, will be greater among racial minorities.

2. Methods

  • Study Design: Our study uses a cross-sectional design analyzing real-world electronic health record (EHR) data from the TriNetX Research Network. The data was collected on November 29, 2023
  • Patient Population: Our study focuses on patients aged 45+ who had healthcare visits between 2017-01-01 and 2018-12-31 to avoid the confounding impact of the COVID-19 pandemic
  • Visual Impairment Classification: Visual impairment was determined using visual disability-related ICD-10 codes (VDRC), categorized as None, Unqualified, Low Vision, and Blindness. Patients with diabetes-related ophthalmology complications were excluded
  • Inclusion Criteria: The study used different inclusion criteria for each research question
  • Outcome Variables:
    • Comorbidities: Our study examined comorbidities related to chronic pulmonary conditions using the Charlson Comorbidity Index (CCI)
    • Standard of care: Having 3+ ambulatory visits annually and receiving 2+ A1C measurements within a year
    • Diabetes Outcomes: Identified indicators like the prevalence of CKD and the rate of uncontrolled diabetes (A1C > 9.0%)
  • Statistical Analysis: We used a risk ratio to evaluate the risk of CKD and uncontrolled diabetes. The differences in proportions test was used to understand how comorbidities vary within the population

3. Statistical Results

3-1. Demography and Diabetes Prevalence

Cohort Race Patient Count Mean Age % Female % with Diabetes % with Diabetes-Related Ophthalmic Complications
No VDRC AA or Black 1,524,072 64 61% 31% 4%
White 9,954,167 67 57% 20% 2%
Asian 456,630 65 61% 23% 3%
VDRC Present AA or Black 22,768 68 55% 58% 23%
White 105,287 72 54% 46% 12%
Asian 3,243 70 56% 47% 17%

3-2. Analysis of the proportion of patients with 3+ Ambulatory visits

Race (-) VDRC, % (+) VDRC, % Δ proportion (p-value) CKD Risk Ratio (p-value) Uncontrolled Diabetes Risk Ratio (p-value)
AA or Black 70.33% 81.15% 10.82% (<0.01) 1.786 (<0.01) 0.968 (0.5)
White 71.84% 81.03% 9.19% (<0.01) 2.274 (<0.01) 0.843 (<0.01)
Asian 63.50% 75.22% 11.72% (<0.01) 1.284 (0.08) 0.847 (0.36)

3-3. Analysis of the proportion of patients with 2+ A1C measures

Race (-) VDRC, % (+) VDRC, % Δ proportion (p-value) CKD Risk Ratio (p-value) Uncontrolled Diabetes Risk Ratio (p-value)
AA or Black 27.66% 28.09% 0.43% (0.55) 1.807 (<0.01) 1.106 (0.08)
White 30.39% 24.95% 5.44% (<0.01) 2.3 (<0.01) 1.108 (0.01)
Asian 32.42% 28.90% 3.52% (0.09) 1.38 (0.02) 0.909 (0.67)

3-4. Analysis of the proportion of patients with 1+ GFR measurements

Race (-) VDRC, % (+) VDRC, % Δ proportion (p-value) CKD Risk Ratio (p-value) Uncontrolled Diabetes Risk Ratio (p-value)
AA or Black 60.20% 64.82% 4.62% (<0.01) 1.751 (<0.01) 0.979 (0.67)
White 53.07% 51.49% 1.58% (<0.01) 2.203 (<0.01) 0.9 (<0.01)
Asian 57.41% 58.53% 1.12% (0.63) 1.242 (0.04) 0.989 (0.95)

3-5. Comorbidity Analysis

This section presents a comorbidity analysis by race, visualizing the prevalence and distribution of key comorbidities among patients with diabetes. The charts below show the comorbidity profiles for African American/Black, White, and Asian populations in the study cohort.

Comorbidity Analysis - AA or Black
Figure 1.a. AA or Black Chronic Pulmonary Disease Prevalence Comparison
Comorbidity Analysis - White
Figure 1.b. White Chronic Pulmonary Disease Prevalence Comparison
Comorbidity Analysis - Asian
Figure 1.c. Asian Chronic Pulmonary Disease Prevalence Comparison

Result:

  • We found a significantly higher burden of chronic pulmonary comorbidities among individuals with visual impairment across all racial groups
  • In all racial cohorts, patients with a visual impairment had a higher prevalence of asthma
    • In the White cohort, 17% of those with a visual impairment had asthma, compared to 10% of those without
    • In the African American population, 20% of those with a visual impairment had asthma, versus 13% of those without
    • In the Asian cohort, the figures were 14% with visual impairment and 9% without
  • This pattern of higher comorbidity burden in patients with visual impairment was also consistent across other diagnoses (i.e., chronic obstructive pulmonary disease, bronchitis)

4. Study Results

Hypothesis 1

Patients with visual impairment will have higher HbA1c and a higher rate of CKD(chronic kidney disease) regardless of race.

Result: There was a mixed result regarding HbA1c levels, but had a consistent result for CKD where individuals with a visual impairment had a higher risk of CKD across all racial groups.

Hypothesis 2

Patients with visual impairment will be less likely to have received the recommended standards of care for diabetes patients.

Result: Individuals with visual impairment had more ambulatory visits, but white people with visual impairment were less likely to have recommended HbA1c testing and the GFR had a mixed result, meaning that the study partially supports the hypothesis that people with visual impairment are less likely to receive recommended standards of care, and the differences in access depend on the type of care and the race of the patient.

Hypothesis 3

The disparities between those with visual impairment and those without these conditions, as identified in hypotheses 1 and 2, will be greater among racial minorities.

Result: While disparities exist, they do not consistently show that racial minorities have greater disparities compared to the White population, suggesting that the study does indicate that there is an interaction between race and visual impairment in determining the quality of care and health outcomes, but in more complex way.